桑志培 博士  副教授 博士/硕士生导师 海南自由贸易港高层次人才

邮箱：sangzhipei@hainanu.edu.cn

一、教育背景及工作经历

2022.08-至今 必赢bwin网页版，副教授

2021.11-2024.11 上海中医药大学，博士后

2019-05至2020-06，新加坡南洋理工大学，博士后

2010-09至2015-06，四川大学华西必赢bwin网页版，硕博连读

2006-09至2010-07，贵州医科大学，药学，学士

二、科研情况

目前研究方向聚焦于人工智能驱动的全新药物设计、成药性优化及作用机制研究”。主持国家自然科学基金、海南省自然科学基金高层次人才项目、中国博士后科学基金面上项目等8项基金，并在Acta Pharm Sin B, J Med Chem, Chinese Chem Lett, Eur J Med Chem, J Agric Food Chem等学术期刊发表论文100余篇,其中以第一或/和通讯作者发表SCI论文55篇（中科院一区16篇，二区15篇，IF大于5的SCI论文有26篇）；参与ELSEVIER出版的AD领域英文专著2部；以第一发明人获得具有自主知识产权的授权发明专利27项（转让1项），实用新型专利5项。

三、研究领域

Ø 人工智能驱动的全新药物设计、成药性优化及作用机制研究

Ø 人工智能驱动的天然活性小分子的发现及活性评价

四、社会兼职

Ø 中国药学会老年药学专业委员会委员

Ø 《药学学报》中、英文两刊青年编委

Ø 《Chinese Chemical Letters》(中国化学快报）青年编委会委员

Ø 《Medicinal Plant Biology》青年编委

Ø 《Marine drugs》期刊的Guest Editor

Ø Advanced Science, Chemical Science, Acta Pharm Sin B, J Med Chem, Chinese Chem Lett, Eur J Med Chem, J Agric Food Chem等期刊杂志审稿人

五、代表性项目

(1) 国家自然科学基金地区基金，“选择性丁酰胆碱酯酶抑制剂的设计、类药性优化及抗AD作用机制研究”，2024.01-2027.12，主持

(2) 海南省自然科学基金高层次人才项目，“丁酰胆碱酯酶选择性抑制剂的合理设计、成药性优化及抗阿尔茨海默症作用研究”，2024.01-2025.12，主持

(3) biwn必赢网址科研启动基金项目，“靶向PDE4的新型抗AD药物研究”，2022.09-2026.12，主持

(4) 中国博士后科学基金第71批面上项目二等资助，“人羧酸酯酶2A特异性共价抑制剂的设计研发、成药性优化及药效学研究”，2022.01-2023.12，主持。

(5) 贵州医科大学 省部共建药用植物功效与利用国家重点实验室开放课题，“杜仲中新型多肽的制备及其活性评价”，2022.01-2023.12，主持。

(6) 贵州医科大学 化学合成药物研发利用工程技术研究中心开放课题，“具有诱导自噬作用的cGN14细胞穿膜环肽的设计、合成及其抗AD活性研究”，2021.08-2022.07，主持。

(7) 河南省科技厅科技攻关项目，“裕丹参中新型多肽的发现及药理活性研究”，2021.01-2022.12，主持

(8) 2020年河南省高等学校重点科研项目，“基于脑靶向的新型高选择性BuChE抑制剂的设计、合成及其抗阿尔茨海默病活性研究”，2020.01-2021.12，主持

(9) 2019年河南省高层次人才国际化培养项目，“口服植物活性肽的研究”，2019.05-2020.06，主持

(10) 河南省自然科学基金，“基于Aβ/AChE双靶点策略的查尔酮衍生物的设计、合成与抗阿尔茨海默病活性研究”，2016.01-2017.12，主持

(11) 2017年河南省高等学校重点科研项目计划，“新型多靶点抑制剂的设计、合成及抗阿尔茨海默症活性研究”，2017.01-2018.12，主持

六、代表性成果（#表示为共同第一，*表示为通讯作者）

(1) Shuheng Huang^#, Ma Chunhua^#, Wenling Fu, Ya Zhang, Chanchan Liang, Yuting Li, Qiyao Zhang, Haopeng Sun^*, Tao Zhang^*, Guang-Bo Ge^*, Zhipei Sang^*. Artificial intelligence-driven development of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease. Nature Communications, 2025 (Under review) (IF = 14.7)

(2) Shuheng Huang^#, Ya Zhang^#, Guang-Hao Zhu^#, Yun-Qing Song^#, Xin-Juan Li^#, Xin-Rui Guo, Hong-Xin Li, Xiao-Yu Zhuang, Ya-Ni Zhang, Meng-Ru Sun, Jian Huang^*, Da-Peng Chen^*, Zhi-Pei Sang^*, Guang-Bo Ge^*. Discovery of novel donepezil-fused chalcones as orally available, potent and selective covalent inhibitors against hCES2A for alleviating irinotecan-induced gut toxicity. Advanced Science, 2025 (Under review) (IF = 14.3)

(3) Zhipei Sang^#(桑志培), Shuheng Huang^#, Wanying Tan^#, Yujuan Ban^#, Keren Wang, Yufan Fan, Hongsong Chen, Qiyao Zhang, Chanchan Liang, Jing Mi, Yunqi Gao, Ya Zhang, Wenmin Liu, Jianta Wang, Wu Dong*, Zhenghuai Tan*, Lei Tang*, Haibin Luo. Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer’s disease. Acta Pharmaceutica Sinica B, 2025, doi: org/10.1016/j.apsb.2025.02.030 (中科院大类一区，IF = 14.8，第一作者)

(4) Zhipei Sang^#(桑志培), Ya Zhang^#, Yufan Fan^#, Changhai Luan, Zhengwei Liu, Qiyao Zhang, Hairong Zeng*, Yunqing Song*, Shuheng Huang*, Guangbo Ge*. AI-driven discovery of highly specific and efficacious hCES2A inhibitors for ameliorating irinotecan-triggered gut toxicity. Journal of Medicinal Chemistry, 2025, 68(6): 6252-6269. (中科院大类一区，IF = 6.9，第一作者)

(5) Qiyao Zhang^#, Yuting Li^#, Qishun Jin^#, Zhengwei Liu^#, Hongsong Chen, Jingqi Huang, Taoyi Liu, Xiaojuan Liu, Zhenghuai Tan, Shuheng Huang*, Wu Dong*, Zhipei Sang^*(桑志培). Artificial intelligence-driven development of natural multi-target derivatives with BuChE inhibitory activity for treating Alzheimer's disease. Chinese Chemical Letters, 2025, doi: 10.1016/j.cclet.2025.110964. (中科院大类一区，IF = 9.4，最后通讯作者)

(6) Yuting Li^#, Qiyao Zhang^#, Xinxin Wang^#, Zhengwei Liu^#, Hongsong Chen, Zhenhui Su, Yidan Xu, Weichang Zhang, Yulu Du, Zhenghuai Tan, Shuheng Huang^*, Wenmin Liu^*, Zhipei Sang^*(桑志培). Development of novel rivastigmine derivatives as selective BuChE inhibitors for the treatment of AD. Bioorganic Chemistry, 2025, 157: 108245. (中科院大类二区，IF = 4.5，最后通讯作者)

(7) Jia C^#, Chai J^#, Zhang S^#, Sun Y, He L, Sang Z^*(桑志培), Chen D^*, Zheng X^*. The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments. Mar Drugs. 2025, 23(3): 91. (中科院大类二区，IF = 4.9，共同通讯作者)

(8) Rui Chen^#, Xinjuan Li^#, Hongsong Chen^#, Keren Wang^#, Teng Xue, Jing Mi, Yujuan Ban, Gaofeng Zhu, Yi Zhou, Wu Dong^*, Lei Tang^*, Zhipei Sang^*(桑志培). Development of the “hidden” multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry. 2023, 251: 115253. (中科院大类一区，IF = 7.088，最后通讯作者)

(9) Hongsong Chen^#, Jing Mi^#, Sen Li^#, Zhengwei Liu, Jing Yang, Rui Chen, Yujie Wang,  Yujuan Ban, Yi Zhou^*, Wu Dong^*, Zhipei Sang^*(桑志培). Design, synthesis and evaluation of quinoline-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023, 38(1): 2169682. (中科院大类二区，IF = 5.756，最后通讯作者)

(10) Zhou Yi^#, He Ying^#, Xue Teng^#, Mi Jing, Yang Jing, Wei Rongrui, Liu Wenmin^*, Ma Qinge^*, Tan Zhenghuai^*, Zhipei Sang^*(桑志培). Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023, 38(1): 2231661. (中科院大类二区，IF = 5.756，最后通讯作者)

(11) Wei RR, Lin QY, Adu M, Huang HL, Yan ZH, Shao F, Zhong GY, Zhang ZL^*, Sang ZP^*(桑志培), Cao L^*, Ma QG^*. The sources, properties, extraction, biosynthesis, pharmacology, and application of lycopene. Food & Function. 2023, 14(22): 9974-9998. (中科院大类一区，IF = 6.1，共同通讯作者)

(12) Ma Qinge^*, Chen Jie, Chen Lihua, Wu Guang, Zhu Meining, He Nengxin, Wang Qinyuan, Sang Zhipei^*(桑志培), Zhu Caiqing, Wu Yongzhong, Wei Rongrui^*. Citrus medica var. Sarcodactylus (Siebold ex Hoola van Nooten) Swingle: an insight into its botany, traditional uses, phytochemistry, and pharmacological properties. Phytochemistry Reviews. 2023, 22(5): 1-33. (中科院大类二区，IF = 7.41，共同通讯作者)

(13) Ma Qinge, He Nengxin, Huang Huilian, Fu Xiaomei, Zhang Zhongli, Shu Jicheng, Wang Qinyuan, Chen Jie, Wu Guang, Zhu Meining, Sang Zhipei^*(桑志培), Cao Lan^*, Wei Rongrui^*. Hippophae rhamnoides L.: A Comprehensive Review on the Botany, Traditional Uses, Phytonutrients, Health Benefits, Quality Markers, and Applications. Journal of Agricultural and Food Chemistry. 2023, 71(12): 4769-4788. (中科院大类一区，IF = 5.895，共同通讯作者)

(14) Zhipei Sang^#,*(桑志培), Keren Wang^#, Jianghong Dong^#, Lei Tang^*. Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress. European Journal of Medicinal Chemistry. 2022, 238: 114464. (中科院大类一区，IF = 7.088，第一/通讯作者)

(15) Zhipei Sang^#,*(桑志培), Ping Bai^#, Yujuan Ban^#, Keren Wang^#, Anguo Wu, Jing Mi,  Jiaqi Hu, Rui Xu, Gaofeng Zhu, Jianta Wang, Jiquan Zhang, Changning Wang^*,Zhenghuai Tan^*, Lei Tang^*. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies. Bioorganic Chemistry. 2022, 127: 106007. (中科院大类一区，IF = 5.307，第一/通讯作者)

(16) Zhipei Sang(桑志培), Qing Song, Zhongcheng Cao, Yong Deng, Li Zhang^*. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 69-85. (中科院大类二区，IF = 5.756，第一作者)

(17) Gaofeng Zhu^#, Ping Bai^#, Keren Wang^#, Jing Mi, Jing Yang, Jiaqi Hu, Yujuan Ban, Rui Xu, Rui Chen, Changning Wang^*, Lei Tang^*, Zhipei Sang^*(桑志培). Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 1375-1388. (中科院大类二区，IF = 5.756，最后通讯作者)

(18) Chan Liu^#, Zhipei Sang^#(桑志培), Hong Pan, Qin Wu, Yu Qiu^*, Jingshan Shi^*. A novel multifunctional 5,6-dimethoxy-indanone-chalcone-carbamate hybrids alleviates cognitive decline in Alzheimer's disease by dual inhibition of acetylcholinesterase and inflammation. Frontiers in Aging Neuroscience. 2022, 14: 922650. (中科院大类二区，IF = 5.702，共同第一作者)

(19) Jing Yang^#, Yi Zhou^#, Yujuan Ban^#, Jing Mi, Ying He, Xinjuan Li, Zhengwei Liu,  Keren Wang, Gaofeng Zhu, Wenmin Liu, Zhenghuai Tan^*, Zhipei Sang^*(桑志培). Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 792-816. (中科院大类二区，IF = 5.756，最后通讯作者)

(20) Ma Qinge, Guan Yang, Sang Zhipei^*(桑志培), Dong Jianghong, Wei Rongrui^*. Isolation and characterization of auronlignan derivatives with hepatoprotective and hypolipidemic activities from the fruits of Hippophae rhamnoides L. Food & Function. 2022, 13(14):7750-7761. (中科院大类一区，IF = 6.317，共同通讯作者)

(21) Zhipei Sang^*,#(桑志培), Qing Song, Zhongcheng Cao, Yong Deng, Zhenghuai Tan,  Li Zhang^*. Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease. European Journal of Medicinal Chemistry. 2021, 216: 113310. (中科院大类一区，IF = 7.088，第一/通讯作者)

(22) Zhipei Sang^*,#(桑志培), Jian Shi^#, Yi Zhou, Keren Wang, Yiyang Zhao, Qingfeng Li ,  Zhanpin Qiao, Anguo Wu^*, Zhenghuai Tan^*, Wenmin Liu^*. Development of genistein-O-alkylamines derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic Chemistry. 2021, 107: 104602. (中科院大类一区，IF = 5.307，第一/通讯作者)

(23) Keren Wang^#, Jian Shi^#, Yi Zhou, Ying He, Jing Mi, Jing Yang, Shuang Liu, Xiangcheng Tang, Wenmin Liu, Zhenghuai Tan^*, Zhipei Sang^*(桑志培). Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer’s disease. Bioorganic Chemistry. 2021, 112：104879. (中科院大类一区，IF = 5.307，最后通讯作者)

(24) Zhipei Sang^*,#(桑志培), Keren Wang^#, Ping Bai^#, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang^*, Zhenghuai Tan^*. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2020, 194: 112265. (中科院大类一区，IF = 6.514，第一/通讯作者)

(25) Zhipei Sang^*,#(桑志培), Keren Wang^#, Jian Shi, Wenmin Liu, Xinfeng Cheng, Gaofeng Zhu, Yiling Wang, Yiyang Zhao, Qiao Zhanpin, Anguo Wu^*, Zhenghuai Tan^*. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2020, 192: 112180. (中科院大类一区，IF = 6.514，第一/通讯作者)

(26) Zhipei Sang^*,#(桑志培), Keren Wang^#, Jian Shi, Xinfeng Cheng, Gaofeng Zhu, Rongrui Wei, Qinge Ma, Lintao Yu, Yiyang Zhao, Zhenghuai Tan^*, Wenmin Liu^*. Apigenin-rivastigmine hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2020, 187: 111958. (中科院大类一区，IF = 6.514，第一/通讯作者)

(27) Sang Zhipei^*,#(桑志培), Wang Keren^#, Zhang Pengfei, Shi Jian, Liu Wenmin^*, Tan Zhenghuai^*. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 180: 238-252. (中科院大类一区，IF = 5.572，第一/通讯作者)

(28) Sang Zhipei^*,#(桑志培), Wang Keren^#, Shi Jian, Liu Wenmin^*, Tan Zhenghuai^*. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 178: 726-739. (中科院大类一区，IF = 5.572，第一/通讯作者)

(29) Bai Ping^#, Wang Keren^#, Zhang Pengfei^#, Shi Jian, Cheng Xinfeng, Zhang Qi, Zheng Cheng, Yang Jian, Lu Xiaoxia^*, Sang Zhipei^*(桑志培). Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 183: 111737. (中科院大类一区，IF = 5.572，通讯作者)

(30) Sang Zhipei^*,#(桑志培), Wang Keren^#, Han Xue, Cao Mengxiao, Tan Zhenghuai^*, Liu Wenmin^*. Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. ACS Chemical Neuroscience. 2019, 10(2): 1008-1024. (中科院大类二区，IF = 4.486，第一/通讯作者)

(31) Sang Zhipei^*(桑志培), Pan Wanli, Wang Keren, Ma Qinge, Yu Lintao, Yang Yan, Bai Ping, Leng Chaoliang, Xu Qian, Li Xiaoqing, Tan Zhenghuai, Liu Wenmin^*. Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivativesas potential multifunctional agents for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2017, 130: 379-392. (中科院大类二区，IF = 4.816，第一/通讯作者)

(32) Sang Zhipei^#(桑志培), Qiang Xiaoming ^#, Li Yan, Xu Rui, Xu Zhongcheng, Song Qing, Wang Ting,  Zhang Xiaoyu, Liu Hongyan, Tan Zhenghuai^*, Deng Yong^*. Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 135: 307-323. (中科院大类二区，IF = 4.816，第一作者)

(33) Zhipei Sang^#(桑志培), Xiaoming Qiang^#, Yan Li^#, Wen Yuan, Qiang Liu, Wei Ang, Yikun Shi, Youfu Luo, Zhenhuai Tan^*, Yong Deng^*, Design, synthesis and evaluation of scutellarein-O-alkylamines as potent multifunctional anti-Alzheimer’s disease agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2015, 94: 348-366. (中科院大类二区，IF = 3.902，第一作者)

(34) Xiaoming Qiang^#, Zhipei Sang^#(桑志培), Wen Yuan, Yan Li, Qiang Liu, Ping Bai, Yikun Shi, Wei Ang, Zhenhuai Tan^*, Yong Deng^*, Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2014, 76: 314-331. (中科院大类二区，IF = 3.343，共同第一作者)

已授权代表性发明专利

(1) 桑志培; 王柯人；柳文敏；时健；程新峰；于林涛. 一种2’-羟基-3苯基苯丙酮化合物及其制备方法和用途. 2022.01.07. 中国 ZL2019106197603.

(2) 桑志培; 王柯人; 柳文敏; 于林涛; 时健; 马倩文; 王慧娟.一种茚酮查尔酮氨基甲酸酯类化合物及其制备方法和用途. 2021.03.30. 中国ZL2019101892884.

(3) 桑志培; 王柯人; 柳文敏; 于林涛; 时健; 程新峰；马倩文. 一种4-氨基甲酸酯-肉桂酰胺-4-苄基哌啶类化合物及其制备方法和用途. 2020.11.03. 中国ZL2019100795872.

(4) 桑志培; 王柯人; 柳文敏; 程新峰; 时健; 于林涛; 冉亚文. 一种芹菜素-O-烷基胺类化合物、制备方法和应用. 2020.06.26. 中国ZL2019100960136. (已转让)

七、课题组学生荣誉奖励（本人作为指导老师）：

(1) 2023年国家级大学生创新创业计划项目立项（项目负责人：2021级药学苏祯惠）

(2) 2023年国家级大学生创新创业计划项目立项（项目负责人：2022级药学邢倩茹）

(3) 第十五届“挑战杯”河南省大学生课外学术科技作品竞赛中荣获“二等奖”两项，2021.06，第一指导教师

(4) 第十三届“挑战杯”河南省大学生课外学术科技作品竞赛二等奖，2017.08.10，第一指导教师

(5) 第八届“国药工程—东富龙杯”全国大学生制药工程设计竞赛二等奖，2018.08，第二指导教师

欢迎有药学、生物学、化学等相关学科背景的同学

报考本课题组的博士/硕士研究生!